![]() ![]() Original Assignee Stichting Dienst Landbouwkundig Onderzoek DLO Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.) ( en Inventor Jeroen Alexander Kortekaas Paulus-Jozef Wichgers Schreur Nadia Dimitrova Oreshkova Robertus Jacobus Maria Moormann Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Granted Application number US14/892,746 Other versions US9750798B2 Google Patents Bunyaviruses with segmented glycoprotein precursor genes and methods for generating these virusesÄownload PDF Info Publication number US20160271241A1 US20160271241A1 US14/892,746 US201414892746A US2016271241A1 US 20160271241 A1 US20160271241 A1 US 20160271241A1 US 201414892746 A US201414892746 A US 201414892746A US 2016271241 A1 US2016271241 A1 US 2016271241A1 Authority US United States Prior art keywords virus bunyavirus rvfv genome segment Prior art date Legal status (The legal status is an assumption and is not a legal conclusion. ![]() Google Patents US20160271241A1 - Bunyaviruses with segmented glycoprotein precursor genes and methods for generating these viruses Several serologic studies conducted in urban areas have shown that the prevalence of LCMV antibodies in human populations range from 2% to 5%.Īdditionally, pregnancy-related infection has been associated with congenital hydrocephalus, chorioretinitis, and mental retardation.US20160271241A1 - Bunyaviruses with segmented glycoprotein precursor genes and methods for generating these viruses The disease has historically been underreported, often making it difficult to determine incidence rates or estimates of prevalence by geographic region. LCMV infections have been reported in Europe, the Americas, Australia, and Japan, and may occur wherever infected rodent hosts of the virus are found. Humans are more likely to contract LCMV from house mice, but infections from pet rodents have also been reported. Other types of rodents, such as hamsters, are not the natural reservoirs but can become infected with LCMV from wild mice at the breeder, in the pet store, or home environment. Infection in house mouse populations may vary by geographic location, though it is estimated that 5% of house mice throughout the United States carry LCMV and are able to transmit virus for the duration of their lives without showing any sign of illness. The primary host of LCMV is the common house mouse, Mus musculus. Lymphocytic choriomeningitis, or LCM, is a rodent-borne viral infectious disease caused by lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae, that was initially isolated in 1933.
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